解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8369
更新日期:2018-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8441
更新日期:2018-06-01 00:00:00
abstract::The warning statement issued by the United States Food and Drug Administration against the use of laparoscopic power morcellators prompted a discussion about the methods of preoperative diagnosis of uterine myometrial lesions. Since 1994, transcervical needle biopsies have been performed to differentiate between uteri...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8425
更新日期:2018-06-01 00:00:00
abstract::Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8368
更新日期:2018-06-01 00:00:00
abstract::The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8388
更新日期:2018-06-01 00:00:00
abstract::Cisplatin-resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin-based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8433
更新日期:2018-06-01 00:00:00
abstract::Death associated protein kinase 1 (DAPK1) is a notable serine/threonine kinase involved in the regulation of multiple cellular pathways, including apoptosis and autophagy. Although DAPK1 is usually considered to be a tumor suppressor, it was previously reported to promote the viability of p53 mutant cancer cell lines ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8439
更新日期:2018-06-01 00:00:00
abstract::Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8357
更新日期:2018-05-01 00:00:00
abstract::Resistance to apoptosis is an characteristic of cancer cells that serves a critical function in tumor development and represents a target for antitumor therapy. Isoimperatorin (ISOIM), a coumarin compound, exhibits antitumor functions in multiple types of tumor cells. However, its antitumor effects and molecular mecha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8303
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to investigate the functional role of Frizzled-7 (FZD7) in the apoptosis of hepatoma cells. HepG2 and Huh-7 hepatocellular carcinoma (HCC) cell lines with FZD7 expression were selected for use in the present study. The small hairpin RNA (shRNA) eukaryotic expression vector specific to ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8292
更新日期:2018-05-01 00:00:00
abstract::Solanine is an alkaloid and is the main extract of the traditional Chinese herb, Solanum nigrum Linn. It has been reported that Solanine has anti-inflammatory and antitumor properties. The present study aimed to investigate the antitumor effect of Solanine in Jurkat cells and demonstrate the molecular mechanism of ant...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8229
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8202
更新日期:2018-05-01 00:00:00
abstract::The present study aimed to investigate the association between insulin-like growth factor-1 (IGF-1) and matrix metalloproteinase-11 (MMP-11) expression in gastric cancer (GC) and the underlying mechanisms in SGC-7901 cells. Reverse transcription-quantitative polymerase chain reaction analysis revealed that the express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8234
更新日期:2018-05-01 00:00:00
abstract::Lung cancer is one of the most lethal types of cancer, and its poor prognosis is primarily due to drug resistance and cancer recurrence. As it is associated with a low five-year survival rate, lung cancer stem cells (LCSCs) have been the subject of numerous recent studies. For these studies of LCSCs, lung cancer cell ...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.8265
更新日期:2018-05-01 00:00:00
abstract::The purpose of the present study was to evaluate the recent trend of diagnosing appendiceal diseases through the analysis of appendectomy materials, stressing the importance of their pathological examination. A clinicopathological assessment of patients undergoing an appendectomy was conducted, based on the pathologic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8134
更新日期:2018-05-01 00:00:00
abstract::Over the latest decade, the role of microRNAs (miRNAs/miRs) has received more attention. miRNAs are small non-coding RNAs that may serve a role as oncogenes or tumor suppressor genes. Certain miRNAs regulate the apoptosis pathway by influencing pro- or anti-apoptotic genes. We hypothesized that increases in the expres...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8336
更新日期:2018-05-01 00:00:00
abstract::Breast cancer is a leading cause of cancer-associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in host cell entry. The ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8344
更新日期:2018-05-01 00:00:00
abstract::Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To the best of our knowledge, the function and regulatory role of miR-532-5p in human CRC remains unknown. The aim of the present study was to determine the role and regulation of miR-532-5p in CRC. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8217
更新日期:2018-05-01 00:00:00
abstract::A number of studies have revealed the usefulness of multimodal imaging in gliomas. Although the results have been heavily affected by the method used for region of interest (ROI) design, the most discriminatory method for setting the ROI remains unclear. The aim of the present study was to determine the most suitable ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8319
更新日期:2018-05-01 00:00:00
abstract::The seven-amino acid truncated (7ND) protein is an N-terminal deletion mutant of monocyte chemoattractant protein-1 (MCP-1) and it functions as a dominant-negative inhibitor. 7ND and wild-type MCP-1 form a heterodimer, which binds to MCP-1 receptors and inhibits monocyte chemotaxis. In the present study, the 7ND prote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8308
更新日期:2018-05-01 00:00:00
abstract::The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8290
更新日期:2018-05-01 00:00:00
abstract::Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8207
更新日期:2018-05-01 00:00:00
abstract::Numerous studies concerning hepatic arterial infusion chemotherapy (HAIC) have been conducted by adopting regimens containing 5-fluorouracil (FU), with a favourable efficacy compared with conventional transcatheter arterial chemoembolisation (TACE) treatment; however, the detailed mechanism of HAIC remains unclear. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8242
更新日期:2018-05-01 00:00:00
abstract::Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8252
更新日期:2018-05-01 00:00:00
abstract::TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8262
更新日期:2018-05-01 00:00:00
abstract::The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8145
更新日期:2018-05-01 00:00:00
abstract::Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8170
更新日期:2018-05-01 00:00:00
abstract::Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8095
更新日期:2018-05-01 00:00:00
abstract::Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea, and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8090
更新日期:2018-05-01 00:00:00
abstract::Xeroderma pigmentosum group C (XPC) is a DNA-damage-recognition gene active at the early stage of DNA repair. XPC also participates in regulation of cell-cycle checkpoint and DNA-damage-induced apoptosis. In the present study, the expression levels of genes involved in nucleotide excision repair (NER) were assessed in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8127
更新日期:2018-05-01 00:00:00
abstract::The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultras...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8122
更新日期:2018-05-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. Currently, 5-fluorouracil (5-FU) remains a widely used chemotherapeutic drug in the treatment of CRC; however, 5-FU resistance during treatment has become a common problem. Livin, a member of the inhibitor of apoptosis pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8282
更新日期:2018-05-01 00:00:00
abstract::Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8027
更新日期:2018-04-01 00:00:00
abstract::The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8048
更新日期:2018-04-01 00:00:00
abstract::The present study describes the case of a 48-year-old man who was diagnosed with lung adenocarcinoma with an epidermal growth factor receptor (EGFR) 21 L858R mutation. The patient received surgery and adjuvant chemotherapy. When multiple lung metastases appeared, icotinib was administered. Following resistance to icot...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8040
更新日期:2018-04-01 00:00:00
abstract::Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8051
更新日期:2018-04-01 00:00:00
abstract::Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8007
更新日期:2018-04-01 00:00:00
abstract::Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in col...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7989
更新日期:2018-04-01 00:00:00
abstract::Andrographolide (Andro), a natural compound isolated from Andrographis paniculata, has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7941
更新日期:2018-04-01 00:00:00
abstract::Numerous studies have indicated that microRNAs (miRs), a group of small non-coding RNAs, are determining regulatory elements involved in the pathogenesis of various types of cancer, including cervical cancer (CC). Although miR-21-5p upregulation has been demonstrated to associate with tumorigenesis by controlling the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7937
更新日期:2018-04-01 00:00:00